Adar^tm1Olds
Targeted Allele Detail

Summary

• Symbol: Adar^tm1Olds
• Name: adenosine deaminase, RNA-specific; targeted mutation 1, Michael B A Oldstone
• MGI ID: MGI:4941203
• Synonyms: Adar1^p150-
• Gene: Adar Location: Chr3:89622329-89660753 bp, + strand Genetic Position: Chr3, 39.19 cM, cytoband F2
• Alliance: Adar^tm1Olds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169014
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Exon 1a was replaced with a floxed neo cassette. This exon is required for isoform p150. (J:169014)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adar Mutation: 72 strains or lines available

References

• Original: J:169014 Ward SV, et al., RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis. Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):331-6
• All: 6 reference(s)