Dpysl5^tm1Gosh
Targeted Allele Detail

Summary

• Symbol: Dpysl5^tm1Gosh
• Name: dihydropyrimidinase-like 5; targeted mutation 1, Yoshio Goshima
• MGI ID: MGI:4941238
• Gene: Dpysl5 Location: Chr5:30868908-30956713 bp, + strand Genetic Position: Chr5, 16.8 cM, cytoband B1
• Alliance: Dpysl5^tm1Gosh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168982
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 6 were replaced with an IRES/lacZ/neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:168982)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dpysl5 Mutation: 35 strains or lines available

References

• Original: J:168982 Yamashita N, et al., CRMP5 (Collapsin Response Mediator Protein 5) Regulates Dendritic Development and Synaptic Plasticity in the Cerebellar Purkinje Cells. J Neurosci. 2011 Feb 2;31(5):1773-9
• All: 2 reference(s)