Nfkbia^tm1.1Smiy
Targeted Allele Detail

Summary

• Symbol: Nfkbia^tm1.1Smiy
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha; targeted mutation 1.1, Shigeki Miyamoto
• MGI ID: MGI:4941306
• Synonyms: Nfkbia^NES
• Gene: Nfkbia Location: Chr12:55536195-55539432 bp, - strand Genetic Position: Chr12, 24.0 cM, cytoband C1-C3
• Alliance: Nfkbia^tm1.1Smiy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168977
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitutions within exon 1 result in three amino acid substitutions, alanine for methionine at position 45 (M45A), alanine for lysine at position 49 (L49A), and alanine for isoleucine at position 52 (I52A). These mutations disrupt the N-terminal nuclear export sequence. The floxed neo cassette inserted downstream of the modified exon 1 was removed by cre-mediated recombination. (J:168977)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nfkbia Mutation: 19 strains or lines available

References

• Original: J:168977 Wuerzberger-Davis SM, et al., Nuclear Export of the NF-kappaB Inhibitor IkappaBalpha Is Required for Proper B Cell and Secondary Lymphoid Tissue Formation. Immunity. 2011 Feb 25;34(2):188-200
• All: 3 reference(s)