Rag2^tm1.1Desi
Targeted Allele Detail

Summary

• Symbol: Rag2^tm1.1Desi
• Name: recombination activating gene 2; targeted mutation 1.1, Stephen Desiderio
• MGI ID: MGI:4941315
• Synonyms: Rag2^T490A
• Gene: Rag2 Location: Chr2:101455063-101462874 bp, + strand Genetic Position: Chr2, 53.87 cM
• Alliance: Rag2^tm1.1Desi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168974
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide subsitution results in the amino acid substitution of alanine for threonine at position 490 (T490A). A floxed neo cassette was removed by cre-mediated recombination. (J:168974)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rag2 Mutation: 119 strains or lines available

References

• Original: J:168974 Zhang L, et al., Coupling of v(d)j recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis. Immunity. 2011 Feb 25;34(2):163-74
• All: 2 reference(s)