Lhx3^tm1.1Sjr
Targeted Allele Detail

Summary

• Symbol: Lhx3^tm1.1Sjr
• Name: LIM homeobox protein 3; targeted mutation 1.1, Simon J Rhodes
• MGI ID: MGI:4941330
• Synonyms: Lhx3^W227ter, Lhx3^W227ter Neo(-)
• Gene: Lhx3 Location: Chr2:26090224-26098261 bp, - strand Genetic Position: Chr2, 18.44 cM, cytoband A2-C1
• Alliance: Lhx3^tm1.1Sjr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169035
• Parent Cell Line: CCE916 (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Single point mutation
• Mutation details: A floxed neo cassette was inserted and a tryptophan to stop mutation was introduced at amino acid 227 via homologous recombination. Cre mediated recombination removed the neo cassette. This mutation results in a truncated protein that lacks the carboxyl terminus. (J:169035)

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lhx3 Mutation: 26 strains or lines available

References

• Original: J:169035 Colvin SC, et al., Model of pediatric pituitary hormone deficiency separates the endocrine and neural functions of the LHX3 transcription factor in vivo. Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):173-8
• All: 2 reference(s)