Gli2^{tm2.1(Gli3)Blnw}
Targeted Allele Detail

Summary

• Symbol: Gli2^{tm2.1(Gli3)Blnw}
• Name: GLI-Kruppel family member GLI2; targeted mutation 2.1, Baolin Wang
• MGI ID: MGI:4941341
• Synonyms: Gli2^3PDD
• Gene: Gli2 Location: Chr1:118761862-118981349 bp, - strand Genetic Position: Chr1, 52.17 cM, cytoband E2-E4
• Alliance: Gli2^{tm2.1(Gli3)Blnw} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169530
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The region coding for amino acid residues 585-751 was replaced with the corresponding region from mouse Gli3 and a floxed neo cassette was inserted via homologous recombination. The replaced region encodes for the processing determining domain. Cre mediated recombination removed the neo cassette. (J:169530)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gli2 Mutation: 169 strains or lines available

References

• Original: J:169530 Li J, et al., Increased proteolytic processing of full-length Gli2 transcription factor reduces the hedgehog pathway activity in vivo. Dev Dyn. 2011 Apr;240(4):766-74
• All: 1 reference(s)