Pik3c3^tm1.1Fawa
Targeted Allele Detail

Summary

• Symbol: Pik3c3^tm1.1Fawa
• Name: phosphatidylinositol 3-kinase catalytic subunit type 3; targeted mutation 1.1, Fan Wang
• MGI ID: MGI:4941351
• Gene: Pik3c3 Location: Chr18:30405800-30481179 bp, + strand Genetic Position: Chr18, 17.41 cM
• Alliance: Pik3c3^tm1.1Fawa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169569
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 17, and an frt flanked neo cassette with a 3' loxP site was inserted downstream of exon 18. The frt sites were mutated and could not be used to remove the neo cassette, which remains intact. Cre mediated recombination removed the floxed region. (J:169569)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3c3 Mutation: 48 strains or lines available

References

• Original: J:169569 Zhou X, et al., The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation. PLoS One. 2011;6(1):e16358
• All: 1 reference(s)