Chrng^{tm2(Chrne)Vwi}
Targeted Allele Detail

Summary

• Symbol: Chrng^{tm2(Chrne)Vwi}
• Name: cholinergic receptor, nicotinic, gamma polypeptide; targeted mutation 2, Veit Witzemann
• MGI ID: MGI:4941453
• Synonyms: gamma/epsilon-fc
• Gene: Chrng Location: Chr1:87133533-87139365 bp, + strand Genetic Position: Chr1, 44.07 cM
• Alliance: Chrng^{tm2(Chrne)Vwi} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169541
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The Chrne cDNA with a point mutation that replaces proline with leucine at position 121 (P121L) and GFP was fused to exon 4 replacing exons 5 and 6. A downstream floxed neo cassette was removed by cre-mediated recombination. (J:169541)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrng Mutation: 31 strains or lines available

References

• Original: J:169541 Pacifici PG, et al., Novel mouse model reveals distinct activity-dependent and -independent contributions to synapse development. PLoS One. 2011;6(1):e16469
• All: 1 reference(s)