Nog^tm1.1Rmh
Targeted Allele Detail

Summary

• Symbol: Nog^tm1.1Rmh
• Name: noggin; targeted mutation 1.1, Richard M Harland
• MGI ID: MGI:4941468
• Synonyms: Nog^fx
• Gene: Nog Location: Chr11:89191464-89193158 bp, - strand Genetic Position: Chr11, 54.34 cM
• Alliance: Nog^tm1.1Rmh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169133
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was placed upstream of the coding region of the Noggin (Nog) gene, and a FRT-flanked neomycin resistance (neo) cassette and a second loxP site were placed downstream. Flp-mediated recombination removed the neo cassette. (J:169133)

Expression

In Mice Carrying this Mutation:	66 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nog Mutation: 18 strains or lines available

References

• Original: J:169133 Stafford DA, et al., Cooperative activity of noggin and gremlin 1 in axial skeleton development. Development. 2011 Mar;138(5):1005-14
• All: 8 reference(s)