Tg(Ncr1-icre)265Sxl
Transgene Detail

Summary

• Symbol: Tg(Ncr1-icre)265Sxl
• Name: transgene insertion 265, Veronika Sexl
• MGI ID: MGI:4941472
• Synonyms: Ncr1-iCreTg
• Transgene: Tg(Ncr1-icre)265Sxl Location: unknown
• Alliance: Tg(Ncr1-icre)265Sxl page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Ncr1-icre)265Sxl expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ncr1 (MGI:1336212)

• Mutation details: A cassette containing codon-improved cre recombinase (icre), an artificial intron, a bovine growth hormone polyadenylation signal, and an ampicillin-resistance gene flanked by FRT sites was recombined into the first exon of the Ncr1 gene contained in BAC RP23-267N11. Recombined BACs were electroporated with a plasmid expressing Flp to delete the ampicillin gene. The final construct was purified and injected into pronuclei of C57BL/6N oocytes. 4 founders (264-267) were generated with 3 demonstrating transgene expression. Line 265 was selected for detailed analysis. (J:169574)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ncr1 (mouse) Summary of all recombinase alleles driven by Ncr1. Alliance mouse Ncr1 gene page

Expression

In Mice Carrying this Mutation:

5 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:169574 Eckelhart E, et al., A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development. Blood. 2011 Feb 3;117(5):1565-73
• All: 28 reference(s)