Tg(Phox2b-cre)1Jke
Transgene Detail

Summary

• Symbol: Tg(Phox2b-cre)1Jke
• Name: transgene insertion 1, Joel K Elmquist
• MGI ID: MGI:4941486
• Synonyms: Phox2b-Cre, Tg(Phox2b-cre)1Lowl
• Transgene: Tg(Phox2b-cre)1Jke Location: unknown
• Alliance: Tg(Phox2b-cre)1Jke page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Phox2b-cre)1Jke expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Phox2b

• Mutation details: A cre recombinase cassette was inserted into the ATG translation start codon of the Phox2b gene contained in a BAC clone by recombineering in bacteria. Correctly recombined clones were injected into C57BL/6J pronucei. Multiple lines were produced and crossed to R26R reporter animals to analyze recombination activity. A line selected for further analysis demonstrating recombination activity in the dorsal motor nucleus of the vagus (DMV) in parasympathetic visceral and brachial motor neurons, with low activity/expression in the nucleus of the solitary tract and area postrema. (J:169562)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Phox2b (species not specified) Summary of all recombinase alleles driven by Phox2b.

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:169562 Rossi J, et al., Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. Cell Metab. 2011 Feb 2;13(2):195-204
• All: 14 reference(s)