Tg(Mt1-CETP)#Tall
Transgene Detail

Summary

• Symbol: Tg(Mt1-CETP)#Tall
• Name: transgene insertion, Alan Tall
• MGI ID: MGI:4941577
• Transgene: Tg(Mt1-CETP)#Tall Location: unknown
• Alliance: Tg(Mt1-CETP)#Tall page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mt1-CETP)#Tall expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  human	CETP (1071)

• Tg(Mt1-CETP)#Tall expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mt1 (MGI:97171)

• Mutation details: A 5' genomic region of the human CETP including 138 base pairs of flanking sequence, exon1, intron 1 and part of exon 2 was linked using a fragment of human CETP cDNA to a 3' sequence of the same gene made up of part of exon 13, exons 14-16, introns 13-15, and 121 base pairs of flanking sequence. The resulting construct lacks introns 2-12. One male and one female founder were identified but a line was established only from the female founder. Only one copy of the transgene was inserted. (J:93800)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:93800 Agellon LB, et al., Reduced high density lipoprotein cholesterol in human cholesteryl ester transfer protein transgenic mice. J Biol Chem. 1991 Jun 15;266(17):10796-801
• All: 5 reference(s)