Madcam1^tm1.2Nwag
Targeted Allele Detail

Summary

• Symbol: Madcam1^tm1.2Nwag
• Name: mucosal vascular addressin cell adhesion molecule 1; targeted mutation 1.2, Norbert Wagner
• MGI ID: MGI:4941725
• Synonyms: MAdCAM-1^delta
• Gene: Madcam1 Location: Chr10:79500393-79504371 bp, + strand Genetic Position: Chr10, 39.72 cM, cytoband C1-C2
• Alliance: Madcam1^tm1.2Nwag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169739
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exons 1 and 2. The absence of protein expression was confirmed by immunohistochemistry on spleen samples. (J:169739)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Madcam1 Mutation: 27 strains or lines available

References

• Original: J:169739 Schippers A, et al., Mucosal addressin cell-adhesion molecule-1 controls plasma-cell migration and function in the small intestine of mice. Gastroenterology. 2009 Sep;137(3):924-33
• All: 8 reference(s)