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Tbc1d4tm1.1Arte
Targeted Allele Detail
Summary
Symbol: Tbc1d4tm1.1Arte
Name: TBC1 domain family, member 4; targeted mutation 1.1, TaconicArtemis
MGI ID: MGI:4941737
Synonyms: AS160T649A
Gene: Tbc1d4  Location: Chr14:101679796-101846627 bp, - strand  Genetic Position: Chr14, 50.9 cM
Alliance: Tbc1d4tm1.1Arte page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:169477
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExon 10 was replaced with an FRT-flanked neo cassette with a 5' loxP site and a modified exon 10 in which nucleotide substitutions result in the amino acid substitution of alanine for threonine at position 649 (T649A) followed by a loxP site. Flp-mediate recombination removed the neo cassette. (J:169477)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbc1d4 Mutation:  51 strains or lines available
References
Original:  J:169477 Chen S, et al., Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking. Cell Metab. 2011 Jan 5;13(1):68-79
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory