Nrxn3^tm3Sud
Targeted Allele Detail

Summary

• Symbol: Nrxn3^tm3Sud
• Name: neurexin III; targeted mutation 3, Thomas C Sudhof
• MGI ID: MGI:4941813
• Synonyms: N3F
• Gene: Nrxn3 Location: Chr12:88689646-90301709 bp, + strand Genetic Position: Chr12, 42.94 cM
• Alliance: Nrxn3^tm3Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224471
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 18 (the first common coding exon for the alpha and beta transcripts) was flanked by loxP sites and an FRT-flanked neomycin selection cassette was placed in the 5' intron. Flp-mediated recombination removed the neo cassette. (J:224471)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nrxn3 Mutation: 80 strains or lines available

References

• Original: J:224471 Aoto J, et al., Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses. Nat Neurosci. 2015 Jul;18(7):997-1007
• All: 16 reference(s)