Usp7^tm1Wgu
Targeted Allele Detail

Summary

• Symbol: Usp7^tm1Wgu
• Name: ubiquitin specific peptidase 7; targeted mutation 1, Wei Gu
• MGI ID: MGI:4941831
• Synonyms: hausp^-, hausp^deltaEx14
• Gene: Usp7 Location: Chr16:8506586-8574931 bp, - strand Genetic Position: Chr16, 4.28 cM
• Alliance: Usp7^tm1Wgu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168184
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES LacZ-neo cassette is inserted into exon 14 of the gene and 29 nucleotides are deleted within exon 14 by targeted homologous recombination. The resulting mutation causes C-terminal truncation and partial deletion of DUB active site domain due to a reading frame shift in protein translation. Western blot confirmed absence of protein product in E8.5 embryo. This is a null allele. (J:168184)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp7 Mutation: 63 strains or lines available

References

• Original: J:168184 Kon N, et al., Inactivation of HAUSP in vivo modulates p53 function. Oncogene. 2010 Mar 4;29(9):1270-9
• All: 2 reference(s)