Gnao1^tm4Lbi
Targeted Allele Detail

Summary

• Symbol: Gnao1^tm4Lbi
• Name: guanine nucleotide binding protein, alpha O; targeted mutation 4, Lutz Birnbaumer
• MGI ID: MGI:4941847
• Synonyms: Galphao^F, Gnao1^fx
• Gene: Gnao1 Location: Chr8:94537213-94696016 bp, + strand Genetic Position: Chr8, 45.94 cM
• Alliance: Gnao1^tm4Lbi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169627
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 5. An additional loxP site was inserted downstream of exon 6. (J:176021)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gnao1 Mutation: 29 strains or lines available

References

• Original: J:169627 Zhao A, et al., Galphao represses insulin secretion by reducing vesicular docking in pancreatic beta-cells. Diabetes. 2010 Oct;59(10):2522-9
• All: 13 reference(s)