Gnao1^tm4.1Lbi
Targeted Allele Detail

Summary

• Symbol: Gnao1^tm4.1Lbi
• Name: guanine nucleotide binding protein, alpha O; targeted mutation 4.1, Lutz Birnbaumer
• MGI ID: MGI:4941848
• Synonyms: Galphao^-
• Gene: Gnao1 Location: Chr8:94537213-94696016 bp, + strand Genetic Position: Chr8, 45.94 cM
• Alliance: Gnao1^tm4.1Lbi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169627
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exons 5 and 6. The predicted product lacks all motifs that bind to adenylyl cyclases, phospholipase C, and betagamma subunits. (J:169627)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gnao1 Mutation: 29 strains or lines available

References

• Original: J:169627 Zhao A, et al., Galphao represses insulin secretion by reducing vesicular docking in pancreatic beta-cells. Diabetes. 2010 Oct;59(10):2522-9
• All: 1 reference(s)