Sla2^tm1Amch
Targeted Allele Detail

Summary

• Symbol: Sla2^tm1Amch
• Name: Src-like-adaptor 2; targeted mutation 1, Alec M Cheng
• MGI ID: MGI:4941869
• Gene: Sla2 Location: Chr2:156716071-156729161 bp, - strand Genetic Position: Chr2, 77.89 cM
• Alliance: Sla2^tm1Amch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169170
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2, 3, and 4 were replaced with a puro cassette. The absence of protein expression was confirmed by western blot analysis on splenocytes and thymocytes. (J:169170)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sla2 Mutation: 25 strains or lines available

References

• Original: J:169170 Liontos LM, et al., The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation. J Immunol. 2011 Feb 15;186(4):1923-33
• All: 2 reference(s)