Ier3^tm1Mxw
Targeted Allele Detail

Summary

• Symbol: Ier3^tm1Mxw
• Name: immediate early response 3; targeted mutation 1, Mei X Wu
• MGI ID: MGI:4941879
• Synonyms: IEX-1 KO
• Gene: Ier3 Location: Chr17:36132605-36133803 bp, + strand Genetic Position: Chr17, 18.7 cM
• Alliance: Ier3^tm1Mxw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157504
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.5 kb region including part of exon 1, all of intron 1 and most of exon 2 was replaced with a lacZ, pgk-neo cassette via homologous recombination. (J:157504)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ier3 Mutation: 11 strains or lines available

References

• Original: J:157504 Akilov OE, et al., Enhanced susceptibility to Leishmania infection in resistant mice in the absence of immediate early response gene X-1. J Immunol. 2009 Dec 15;183(12):7994-8003
• All: 7 reference(s)