Pink1^tm1Hbu
Targeted Allele Detail

Summary

• Symbol: Pink1^tm1Hbu
• Name: PTEN induced putative kinase 1; targeted mutation 1, Hansruedi Bueler
• MGI ID: MGI:4941901
• Gene: Pink1 Location: Chr4:138040720-138053618 bp, - strand Genetic Position: Chr4, 70.14 cM
• Alliance: Pink1^tm1Hbu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169471
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neo cassette with a 3' loxP site replaced exons 4 and 5. The absence of transcript expression was confirmed by RT-PCR. (J:169471)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pink1 Mutation: 43 strains or lines available

References

• Original: J:169471 Akundi RS, et al., Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice. PLoS One. 2011;6(1):e16038
• All: 10 reference(s)