Prickle2^tm1Nue
Targeted Allele Detail

Summary

• Symbol: Prickle2^tm1Nue
• Name: prickle planar cell polarity protein 2; targeted mutation 1, Naoto Ueno
• MGI ID: MGI:4941925
• Gene: Prickle2 Location: Chr6:92347889-92683136 bp, - strand Genetic Position: Chr6, 41.05 cM
• Alliance: Prickle2^tm1Nue page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169136
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exons 4, 5, and 6. The absence of transcript expression was confirmed by in situ hybridization on brain samples. (J:169136)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prickle2 Mutation: 52 strains or lines available

References

• Original: J:169136 Tao H, et al., Mutations in prickle orthologs cause seizures in flies, mice, and humans. Am J Hum Genet. 2011 Feb 11;88(2):138-49
• All: 7 reference(s)