About   Help   FAQ
Nkx2-1tm2Rdl
Targeted Allele Detail
Summary
Symbol: Nkx2-1tm2Rdl
Name: NK2 homeobox 1; targeted mutation 2, Roberto Di Lauro
MGI ID: MGI:4941951
Synonyms: Nkx2-1deltaNH2
Gene: Nkx2-1  Location: Chr12:56578741-56583570 bp, - strand  Genetic Position: Chr12, 24.42 cM, cytoband C1-C3
Alliance: Nkx2-1tm2Rdl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:169693
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe 5' coding region was removed and a neo cassette was inserted downstream of the coding region. The predicted protein product lacks the N-terminal amino acids (1-159). (J:169693)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx2-1 Mutation:  24 strains or lines available
References
Original:  J:169693 Silberschmidt D, et al., In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1. BMC Dev Biol. 2011;11:9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/22/2024
MGI 6.24
The Jackson Laboratory