Nkx2-1^tm3Rdl
Targeted Allele Detail

Summary

• Symbol: Nkx2-1^tm3Rdl
• Name: NK2 homeobox 1; targeted mutation 3, Roberto Di Lauro
• MGI ID: MGI:4941952
• Synonyms: Nkx2-1^deltaCOOH
• Gene: Nkx2-1 Location: Chr12:56578741-56583570 bp, - strand Genetic Position: Chr12, 24.42 cM, cytoband C1-C3
• Alliance: Nkx2-1^tm3Rdl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169693
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 3' coding region was removed and a neo cassette was inserted downstream of the coding region. The predicted protein product lacks the C-terminal amino acids (221-372). (J:169693)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx2-1 Mutation: 24 strains or lines available

References

• Original: J:169693 Silberschmidt D, et al., In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1. BMC Dev Biol. 2011;11:9
• All: 1 reference(s)