Tg(LRRK2*G2019S)1Cjli
Transgene Detail

Summary

• Symbol: Tg(LRRK2*G2019S)1Cjli
• Name: transgene insertion 1, Chenjian Li
• MGI ID: MGI:4942189
• Synonyms: G/S LRRK2
• Transgene: Tg(LRRK2*G2019S)1Cjli Location: unknown
• Alliance: Tg(LRRK2*G2019S)1Cjli page

Transgene origin

• Strain of Origin: FVB/NTac

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(LRRK2*G2019S)1Cjli expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LRRK2 (120892)

  Lrrk2

  (MGI:1913975)

• Mutation details: A 188 Kb bacterial artificial chromosome (BAC) containing the entire human LRRK2 (leucine-rich repeat kinase 2) gene was modified by targeted mutation of the LRRK2 locus to harbor the LRRK2 G2019S mutation associated with autosomal dominant, late-onset Parkinson's disease. (J:169825)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:169825 Li C, A new transgenic mouse expressing mutant human LRRK2 (G2019S), a model for Parkinson's disease. MGI Direct Data Submission. 2011
• All: 10 reference(s)