Tg(CAG-EGFP,-PAX8/PPARG)1Rkoe
Transgene Detail

Summary

• Symbol: Tg(CAG-EGFP,-PAX8/PPARG)1Rkoe
• Name: transgene insertion 1, Ronald J Koenig
• MGI ID: MGI:4942191
• Synonyms: PPFP, Tg(CAG-EGFP,-PAX8/PPARG)1Rjk
• Transgene: Tg(CAG-EGFP,-PAX8/PPARG)1Rkoe Location: unknown
• Alliance: Tg(CAG-EGFP,-PAX8/PPARG)1Rkoe page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-EGFP,-PAX8/PPARG)1Rkoe expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PAX8 (7849)

  Pax8	(MGI:97492)

  human

  PPARG (5468)

  Pparg

  (MGI:97747)

• Mutation details: The CAG promoter drives expression of a floxed EGFP followed by the fusion of human PAX8 and PPARG. Cre-mediated recombination is required to remove the floxed EGFP cassette and allow for expression of the fusion protein. This fusion protein is expressed in 35% of human follicular thyroid carcinomas. (J:177181)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:177181 Dobson ME, et al., Pioglitazone Induces a Proadipogenic Antitumor Response in Mice with PAX8-PPAR{gamma} Fusion Protein Thyroid Carcinoma. Endocrinology. 2011 Nov;152(11):4455-65
• All: 3 reference(s)