Tg(Kit*D814V)3Roer
Transgene Detail

Summary

• Symbol: Tg(Kit*D814V)3Roer
• Name: transgene insertion 3, Axel Roers
• MGI ID: MGI:4942359
• Synonyms: kit^D814Vflox
• Transgene: Tg(Kit*D814V)3Roer Location: unknown
• Alliance: Tg(Kit*D814V)3Roer page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Kit*D814V)3Roer expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Kit (MGI:96677)

• Mutation details: This transgene consists of the mouse BAC clone RP23-274L11 which contains the entire Kit locus. The Kit locus in the BAC was modified by the insertion of a floxed stop cassette into intron 1 and the insertion of an A to T point mutation in exon 17 resulting in an aspartic acid to valine mutation at position 814. This mutation is homologous to the D816V mutation in humans. This line carries 2 copies of the transgene. Analysis of the residual vector backbone indicates the transgenes in this line may not be intact. (J:169611)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:169611 Gerbaulet A, et al., Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit. Blood. 2011 Feb 10;117(6):2012-21
• All: 1 reference(s)