Aicda^tm2.1Hon
Targeted Allele Detail

Summary

• Symbol: Aicda^tm2.1Hon
• Name: activation-induced cytidine deaminase; targeted mutation 2.1, Tasuku Honjo
• MGI ID: MGI:4942397
• Synonyms: Aicda^G23S
• Gene: Aicda Location: Chr6:122530768-122541139 bp, + strand Genetic Position: Chr6, 57.65 cM, cytoband F2
• Alliance: Aicda^tm2.1Hon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169227
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 2 was replaced with one in which nucleotide substitutions result in the amino acid substitution of serine for glycine at position 23 (G23S). A floxed neo cassette inserted downstream of exon 3 was removed by cre-mediated recombination. (J:169227)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Aicda Mutation: 57 strains or lines available

References

• Original: J:169227 Wei M, et al., Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense. Nat Immunol. 2011 Mar;12(3):264-70
• All: 5 reference(s)