Itpa^tm1Skmi
Targeted Allele Detail

Summary

• Symbol: Itpa^tm1Skmi
• Name: inosine triphosphatase (nucleoside triphosphate pyrophosphatase); targeted mutation 1, Kunihiko Sakumi
• MGI ID: MGI:4942407
• Gene: Itpa Location: Chr2:130509530-130523534 bp, + strand Genetic Position: Chr2, 63.24 cM, cytoband F3
• Alliance: Itpa^tm1Skmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169285
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exons 2, 3, and 4. The absence of protein expression was confirmed by western blot analysis on brain and liver extract. (J:169285)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itpa Mutation: 23 strains or lines available

References

• Original: J:169285 Behmanesh M, et al., ITPase-deficient mice show growth retardation and die before weaning. Cell Death Differ. 2009 Oct;16(10):1315-22
• All: 2 reference(s)