Grhl2^m1Nisw
Chemically induced Allele Detail

Summary

• Symbol: Grhl2^m1Nisw
• Name: grainyhead like transcription factor 2; mutation 1, Lee Niswander
• MGI ID: MGI:4942413
• Synonyms: Grhl2^1Nisw
• Gene: Grhl2 Location: Chr15:37233280-37363813 bp, + strand Genetic Position: Chr15, 14.84 cM, cytoband C
• Alliance: Grhl2^m1Nisw page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU induced a T to A transversion at position 37,200,529 on chromosome 15 that results in the production of a premature stop codon. The predicted product contains 52 amino acids compared with the full length 625 amino acids. (J:169829)

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grhl2 Mutation: 41 strains or lines available

References

• Original: J:169829 Pyrgaki C, et al., Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion. Dev Biol. 2011 May 1;353(1):38-49
• All: 3 reference(s)