Shroom3^m1Nisw
Chemically induced Allele Detail

Summary

• Symbol: Shroom3^m1Nisw
• Name: shroom family member 3; mutation 1, Lee Niswander
• MGI ID: MGI:4943186
• Gene: Shroom3 Location: Chr5:92831294-93113177 bp, + strand Genetic Position: Chr5, 47.29 cM, cytoband E3
• Alliance: Shroom3^m1Nisw page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Nucleotide substitutions
• Mutation details: Following multidose N-ethyl-N-nitrosourea (ENU) treatments to induce mutations in founder C57BL/6J mice, a forward genetic screen was utilized to identify mice exhibiting defects in the closure of embryonic fissures (including the neural tube, body wall, and face). A single nucleotide polymorphism (SNP) was found, resulting in a C to T transition. This caused an arginine to cysteine change in exon 9. (J:169831)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Shroom3 Mutation: 206 strains or lines available

References

• Original: J:169831 Niswander L, Direct Data Submission 2011/03/29. MGI Direct Data Submission. 2011
• All: 4 reference(s)