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Pcsk9tm1.2Prat
Targeted Allele Detail
Summary
Symbol: Pcsk9tm1.2Prat
Name: proprotein convertase subtilisin/kexin type 9; targeted mutation 1.2, Annik Prat
MGI ID: MGI:4943496
Gene: Pcsk9  Location: Chr4:106299531-106321522 bp, - strand  Genetic Position: Chr4, 49.67 cM
Alliance: Pcsk9tm1.2Prat page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:169834
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe proximal promoter and exon 1 were flanked by loxP sites and an FRT flanked neomycin selection cassette was inserted just downstream of the loxP site in intron 1. The neomycin selection cassette was subsequently excised by flp recombinase expression after crossing to Gt(ROSA)26Sor mice and cre expression after crossing to Tg(CMV-cre)1Ipc mice resulted in excision of the proximal promoter and exon 1. (J:169834)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pcsk9 Mutation:  46 strains or lines available
References
Original:  J:169834 Zaid A, et al., Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration. Hepatology. 2008 Aug;48(2):646-54
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory