Tg(Apoe-Pcsk9*H229A)#Prat
Transgene Detail

Summary

• Symbol: Tg(Apoe-Pcsk9*H229A)#Prat
• Name: transgene insertion, Annik Prat
• MGI ID: MGI:4943505
• Synonyms: TgHA
• Transgene: Tg(Apoe-Pcsk9*H229A)#Prat Location: unknown
• Alliance: Tg(Apoe-Pcsk9*H229A)#Prat page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Apoe-Pcsk9*H229A)#Prat expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pcsk9 (MGI:2140260)	Transgene codes for a protein with a histidine to alanin mutation.

• Mutation details: A Pcsk9 DNA construct with an H229A active site mutation was placed under the control of an Apoe promoter and a liver specific enhancer. mRNA expression was 40 fold higher than normal. (J:169834)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:169834 Zaid A, et al., Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration. Hepatology. 2008 Aug;48(2):646-54
• All: 1 reference(s)