Rsad2^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Rsad2^tm1Aki
• Name: radical S-adenosyl methionine domain containing 2; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:4943550
• Gene: Rsad2 Location: Chr12:26492745-26506451 bp, - strand Genetic Position: Chr12, 9.69 cM, cytoband A3
• Alliance: Rsad2^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169840
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exons 1 and 2. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblasts treated with IFNbeta. (J:169840)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rsad2 Mutation: 28 strains or lines available

References

• Original: J:169840 Saitoh T, et al., Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells. Immunity. 2011 Mar 25;34(3):352-63
• All: 1 reference(s)