Tlr4^Lps-d+
Spontaneous Allele Detail

Summary

• Symbol: Tlr4^Lps-d+
• Name: toll-like receptor 4; lipopolysaccharide response wild-type revertant
• MGI ID: MGI:4943781
• Gene: Tlr4 Location: Chr4:66745788-66765338 bp, + strand Genetic Position: Chr4, 34.66 cM
• Alliance: Tlr4^Lps-d+ page

Mutation origin

• Strain of Origin: C3H/HeJArc

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: This revertant to wild-type of the Tlr4^Lps-d, defective lipopolysaccharide response, allele was identified in a screen for LPS responsiveness of several C3H/He sublines maintained at Australian facilities. Sequence analysis of Tlr4 in the vicinity of the original mutation, which replaced C with A at nucleotide position 2342 and changed a triplet (CCT) encoding proline with a codon (CAT) for histidine in the third exon, demonstrated that C3H/HeJArc and its derivative congenic strains bear a Tlr4 allele identical in sequence to wild-type. As Tlr4^Lps-d occurred in C3H/HeJ between 1958 and 1965 (J:5919) and C3H/HeJArc has been maintained at the Animal Resources Centre (subsequently acquired by Ozgene) in Murdoch, WA, Australia since no earlier than 1971 (J:169915), the apparent wild-type allele in this strain is presumed to have arisen by reverse mutation. (J:169915)
• Inheritance: Codominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr4 Mutation: 91 strains or lines available

References

• Original: J:169915 Silvia OJ, et al., Variations in LPS responsiveness among different mouse substrains of C3H lineage and their congenic derivative sublines. Immunogenetics. 1999 Dec;50(5-6):354-7
• All: 1 reference(s)