Lrrk2^tm1.1Mjff
Targeted Allele Detail

Summary

• Symbol: Lrrk2^tm1.1Mjff
• Name: leucine-rich repeat kinase 2; targeted mutation 1.1, The Michael J Fox Foundation
• MGI ID: MGI:4943782
• Synonyms: Lrrk2^tm1.1Youy
• Gene: Lrrk2 Location: Chr15:91557378-91700323 bp, + strand Genetic Position: Chr15, 46.07 cM, cytoband F1
• Alliance: Lrrk2^tm1.1Mjff page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170000
• Parent Cell Line: ART B6-3, B6-3 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exons 39-40 of the leucine-rich repeat kinase 2 (Lrrk2) gene with a loxP-flanked neomycin resistance (neo) cassette. Correctly targeted ES cells were transiently transfected with a Cre recombinase expression plasmid to delete the neo cassette. Correctly targeted ES cells were injected into blastocysts and resulting chimeric mice were bred to C57BL/6NTac mice. (J:170000)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrrk2 Mutation: 159 strains or lines available

References

• Original: J:170000 Ouyang Y, Generation of a new Lrrk2 knockout allele. MGI Direct Data Submission. 2011
• All: 19 reference(s)