Maoa^tm1Shih
Targeted Allele Detail

Summary

• Symbol: Maoa^tm1Shih
• Name: monoamine oxidase A; targeted mutation 1, Jean C Shih
• MGI ID: MGI:4946240
• Synonyms: MAO-A^neo
• Gene: Maoa Location: ChrX:16485937-16554051 bp, + strand Genetic Position: ChrX, 11.78 cM, cytoband A2
• Alliance: Maoa^tm1Shih page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170067
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 12. A floxed neo cassette was inserted downstream of exon 12. No enzymatic activity was detected. Removal of the neo cassette is required to restore enzymatic activity. (J:170067, J:193013)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Maoa Mutation: 11 strains or lines available

References

• Original: J:170067 Kaludercic N, et al., Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload. Circ Res. 2010 Jan 8;106(1):193-202
• All: 8 reference(s)