Nr1h3^tm1.1Nph
Targeted Allele Detail

Summary

• Symbol: Nr1h3^tm1.1Nph
• Name: nuclear receptor subfamily 1, group H, member 3; targeted mutation 1.1, N P Hessvik
• MGI ID: MGI:4946259
• Gene: Nr1h3 Location: Chr2:91014406-91033179 bp, - strand Genetic Position: Chr2, 50.52 cM
• Alliance: Nr1h3^tm1.1Nph page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169945
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassetted was inserted upstream of exon 2. A loxP site was inserted downstream of exon 7. Cre-mediated recombination removed exons 2 through 7 and the neo cassette. The absence of transcript expression was confirmed by RT-PCR. (J:169945)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr1h3 Mutation: 32 strains or lines available

References

• Original: J:169945 Hessvik NP, et al., LXR{beta} is the dominant LXR subtype in skeletal muscle regulating lipogenesis and cholesterol efflux. Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E602-13
• All: 1 reference(s)