Aqp4^tm1.1Lmno
Targeted Allele Detail

Summary

• Symbol: Aqp4^tm1.1Lmno
• Name: aquaporin 4; targeted mutation 1.1, Laboratory for Molecular Neuroscience
• MGI ID: MGI:4946403
• Gene: Aqp4 Location: Chr18:15522553-15544039 bp, - strand Genetic Position: Chr18, 8.74 cM
• Alliance: Aqp4^tm1.1Lmno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168686
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. Cre-mediated recombination removed exons 1 through 3 and the neo cassette. The absence of protein expression was confirmed by western blot analysis. (J:168686)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aqp4 Mutation: 46 strains or lines available

References

• Original: J:168686 Thrane AS, et al., Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):846-51
• All: 27 reference(s)