Mtf2^tm1.1Hko
Targeted Allele Detail

Summary

• Symbol: Mtf2^tm1.1Hko
• Name: metal response element binding transcription factor 2; targeted mutation 1.1, Haruhiko Koseki
• MGI ID: MGI:4946491
• Synonyms: Pcl2^delta
• Gene: Mtf2 Location: Chr5:108213540-108256870 bp, + strand Genetic Position: Chr5, 52.41 cM
• Alliance: Mtf2^tm1.1Hko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170279
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 and part of exon 5 were replaced with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. The absence of protein expression was confirmed by western blot analysis on whole cell extracts. (J:170279)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtf2 Mutation: 314 strains or lines available

References

• Original: J:170279 Li X, et al., Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes. Mol Cell Biol. 2011 Jan;31(2):351-64
• All: 1 reference(s)