Pld6^tm1.1Mafr
Targeted Allele Detail

Summary

• Symbol: Pld6^tm1.1Mafr
• Name: phospholipase D family member 6; targeted mutation 1.1, Michael A Frohman
• MGI ID: MGI:4946513
• Gene: Pld6 Location: Chr11:59674723-59678471 bp, - strand Genetic Position: Chr11, 37.79 cM
• Alliance: Pld6^tm1.1Mafr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169933
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked and second loxP site were inserted downstream of exon 2 via homologous recombination. Cre mediated recombination deleted exon 2 and the neo cassette. (J:169933)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pld6 Mutation: 9 strains or lines available

References

• Original: J:169933 Huang H, et al., piRNA-Associated Germline Nuage Formation and Spermatogenesis Require MitoPLD Profusogenic Mitochondrial-Surface Lipid Signaling. Dev Cell. 2011 Mar 15;20(3):376-87
• All: 1 reference(s)