Slc6a4^tm1.1Rbl
Targeted Allele Detail

Summary

• Symbol: Slc6a4^tm1.1Rbl
• Name: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; targeted mutation 1.1, Randy D Blakely
• MGI ID: MGI:4946603
• Synonyms: Sert^M172
• Gene: Slc6a4 Location: Chr11:76889429-76923166 bp, + strand Genetic Position: Chr11, 46.18 cM
• Alliance: Slc6a4^tm1.1Rbl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170356
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 4 was replaced with a modified one in which nucleotide substitutions result in the amino acid substitution of methionine for isoleucine at position 172 (I172M). A floxed neo cassette inserted downstream of exon 4 was removed by cre-mediated recombination. (J:170356)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc6a4 Mutation: 53 strains or lines available

References

• Original: J:170356 Thompson BJ, et al., Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3785-90
• All: 5 reference(s)