Slc5a2^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Slc5a2^tm1Lex
• Name: solute carrier family 5 (sodium/glucose cotransporter), member 2; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:4946611
• Synonyms: Sglt2^-
• Gene: Slc5a2 Location: Chr7:127864855-127871602 bp, + strand Genetic Position: Chr7, 70.08 cM, cytoband F4
• Alliance: Slc5a2^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169917
• Parent Cell Line: Lex-2 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A beta-geo cassette replaced exons 1 through 5. The absence of protein expression was confirmed by western blot analysis on kidney extracts. (J:169917)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc5a2 Mutation: 35 strains or lines available

References

• Original: J:169917 Vallon V, et al., SGLT2 mediates glucose reabsorption in the early proximal tubule. J Am Soc Nephrol. 2011 Jan;22(1):104-12
• All: 8 reference(s)