Hic1^tm1.1Kori
Targeted Allele Detail

Summary

• Symbol: Hic1^tm1.1Kori
• Name: hypermethylated in cancer 1; targeted mutation 1.1, Vladimir Korinek
• MGI ID: MGI:4946618
• Synonyms: Hic1^flox
• Gene: Hic1 Location: Chr11:75055391-75060345 bp, - strand Genetic Position: Chr11, 45.76 cM
• Alliance: Hic1^tm1.1Kori page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170337
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked flpe-neo cassette with a 5' loxP site was inserted downstream of exon 1. A loxP site was inserted downstream of the coding region of exon 2. Flp-mediated recombination removed the flpe-neo cassette. (J:170337)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hic1 Mutation: 36 strains or lines available

References

• Original: J:170337 Pospichalova V, et al., Generation of two modified mouse alleles of the Hic1 tumor suppressor gene. Genesis. 2011 Mar;49(3):142-51
• All: 5 reference(s)