Hic1^tm2.1Kori
Targeted Allele Detail

Summary

• Symbol: Hic1^tm2.1Kori
• Name: hypermethylated in cancer 1; targeted mutation 2.1, Vladimir Korinek
• MGI ID: MGI:4946620
• Synonyms: Hic1^cit
• Gene: Hic1 Location: Chr11:75055391-75060345 bp, - strand Genetic Position: Chr11, 45.76 cM
• Alliance: Hic1^tm2.1Kori page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170337
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked flpe-neo cassette was inserted upstream of exon 2. Most of exon 2 was replaced with a citrine gene. Flp-mediated recombination removed the flpe-neo cassette. (J:170337)

Expression

In Mice Carrying this Mutation:

67 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hic1 Mutation: 36 strains or lines available

References

• Original: J:170337 Pospichalova V, et al., Generation of two modified mouse alleles of the Hic1 tumor suppressor gene. Genesis. 2011 Mar;49(3):142-51
• All: 4 reference(s)