Tdrd5^tm1Sait
Targeted Allele Detail

Summary

• Symbol: Tdrd5^tm1Sait
• Name: tudor domain containing 5; targeted mutation 1, Mitinori Saitou
• MGI ID: MGI:4946629
• Gene: Tdrd5 Location: Chr1:156082866-156131234 bp, - strand Genetic Position: Chr1, 67.71 cM, cytoband G3
• Alliance: Tdrd5^tm1Sait page

Sterility in Tdrd5^tm1Sait/Tdrd5^tm1Sait males

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170319
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exons 10 and 11. The absence of protein expression was confirmed by western blot analysis on testes extract. (J:170319)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tdrd5 Mutation: 41 strains or lines available

References

• Original: J:170319 Yabuta Y, et al., TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice. J Cell Biol. 2011 Mar 7;192(5):781-95
• All: 1 reference(s)