Ciao3^tm1.1Fsl
Targeted Allele Detail

Summary

• Symbol: Ciao3^tm1.1Fsl
• Name: cytosolic iron-sulfur assembly component 3; targeted mutation 1.1, Frank Lee
• MGI ID: MGI:4946831
• Synonyms: Iop1 f
• Gene: Ciao3 Location: Chr17:25992750-26002306 bp, + strand Genetic Position: Chr17, 12.88 cM
• Alliance: Ciao3^tm1.1Fsl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170523
• Parent Cell Line: EAP6 (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 1 followed by an frt-flanked neomycin resistance (neo) cassette, and a second loxP site downstream of exon 1 of the nuclear prelamin A recognition factor-like (Narfl or Iop1) gene. Flp-mediated recombination removed the neo cassette. (J:170523)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ciao3 Mutation: 29 strains or lines available

References

• Original: J:170523 Song D, et al., Mouse knock-out of IOP1 protein reveals its essential role in mammalian cytosolic iron-sulfur protein biogenesis. J Biol Chem. 2011 May 6;286(18):15797-805
• All: 1 reference(s)