Tcf7l2^{tm1.1(EGFP/cre)Mrc}
Targeted Allele Detail

Summary

• Symbol: Tcf7l2^{tm1.1(EGFP/cre)Mrc}
• Name: transcription factor 7 like 2, T cell specific, HMG box; targeted mutation 1.1, Mario R Capecchi
• MGI ID: MGI:4946909
• Synonyms: Tcf4^Cre
• Gene: Tcf7l2 Location: Chr19:55730252-55922086 bp, + strand Genetic Position: Chr19, 51.59 cM
• Alliance: Tcf7l2^{tm1.1(EGFP/cre)Mrc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170088
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Tcf7l2^{tm1.1(EGFP/cre)Mrc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tcf7l2 (MGI:1202879)

• Mutation details: An EGFP/cre fusion and an FRT-flanked neo cassette replaced exon 1. Flp-mediated recombination removed the neo cassette. The absence of protein expression was confirmed by immunohistochemistry on E16.5 small intestine and colon samples. (J:170088)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tcf7l2 (mouse) Summary of all recombinase alleles driven by Tcf7l2. Alliance mouse Tcf7l2 gene page

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tcf7l2 Mutation: 58 strains or lines available

Notes

ES cell line = R1-45 derived from (129X1/SvJ x 129S1/Sv)F1-Kitl+

References

• Original: J:170088 Angus-Hill ML, et al., T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4914-9
• All: 2 reference(s)