Tcf7l2^tm2.1Mrc
Targeted Allele Detail

Summary

• Symbol: Tcf7l2^tm2.1Mrc
• Name: transcription factor 7 like 2, T cell specific, HMG box; targeted mutation 2.1, Mario R Capecchi
• MGI ID: MGI:4946910
• Synonyms: Tcf4^Lox, Tcf4^loxEx1Lox
• Gene: Tcf7l2 Location: Chr19:55730252-55922086 bp, + strand Genetic Position: Chr19, 51.59 cM
• Alliance: Tcf7l2^tm2.1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170088
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 1 was replaced with a floxed exon 1 and an FRT-flanked neo cassette. Flp-mediated recombination removed the neo cassette. (J:170088)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tcf7l2 Mutation: 58 strains or lines available

Notes

ES cell line = G456

References

• Original: J:170088 Angus-Hill ML, et al., T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4914-9
• All: 9 reference(s)