Tcf7l2^tm2.2Mrc
Targeted Allele Detail

Summary

• Symbol: Tcf7l2^tm2.2Mrc
• Name: transcription factor 7 like 2, T cell specific, HMG box; targeted mutation 2.2, Mario R Capecchi
• MGI ID: MGI:4946911
• Synonyms: Tcf4^delta
• Gene: Tcf7l2 Location: Chr19:55730252-55922086 bp, + strand Genetic Position: Chr19, 51.59 cM
• Alliance: Tcf7l2^tm2.2Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170088
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exon 1 from Tcf7l2^tm2.1Mrc. The absence of protein expression was confirmed by immunohistochemistry on E16.5 small intestine and colon samples. (J:170088)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf7l2 Mutation: 58 strains or lines available

References

• Original: J:170088 Angus-Hill ML, et al., T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4914-9
• All: 3 reference(s)